[Relationship among the expression of lymphatic vessel density, microvessel density, carcinoembryonic antigenic mRNA, KAI1, and Kiss-1, and prognosis in patients with non-small cell lung cancer].
Zhongguo Fei Ai Za Zhi
; 15(6): 348-54, 2012 Jun.
Article
en Zh
| MEDLINE
| ID: mdl-22681921
ABSTRACT
BACKGROUND AND OBJECTIVE:
In recent years, many studies have revealed the prognosis in patients with non-small cell lung cancer (NSCLC). In general, some clinic-pathological parameters have been related with prognosis. The aim of this study is to detect the relationship among lymphatic vessel density (LVD), microvessel density (MVD), expression of carcinoembryonic antigen (CEA) mRNA, metastasis suppressor genes (KAI1 and Kiss-1), and the prognosis of NSCLC patients.METHODS:
Blood samples were collected from 57 cases of NSCLC. The transcription of CEA mRNA was detected via nested reverse transcriptase-polymerase chain reaction and micro-fluid chip. Immunohistochemistry was performed to detect the expression of LVD, MVD, KAI1 and Kiss-1 in the patients. All follow-up data were collected and analyzed.RESULTS:
The overall five-year survival rate was 18%, and the median survival was 34 months. TNM stage, lymph node metastasis, and expression of MVD, LVD, CEA mRNA and Kiss-1 were factors to survival, as determined via single survival analysis. Multivariate analysis demonstrated that TNM stage, lymph node metastasis, and expression of CEA mRNA were independent prognostic factors for NSCLC patients.CONCLUSIONS:
The expression of MVD, LVD, Kiss-1 and CEA mRNA is related to the prognosis of NSCLC.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Regulación Neoplásica de la Expresión Génica
/
Carcinoma de Pulmón de Células no Pequeñas
/
Vasos Linfáticos
/
Microvasos
/
Neoplasias Pulmonares
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Idioma:
Zh
Revista:
Zhongguo Fei Ai Za Zhi
Asunto de la revista:
NEOPLASIAS
Año:
2012
Tipo del documento:
Article