Bartter syndrome and growth hormone deficiency: three cases.
Pediatr Nephrol
; 27(11): 2145-2148, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-22707176
ABSTRACT
BACKGROUND:
Bartter syndrome is a rare autosomal recessive disorder characterized by hypokalemia, salt loss, and metabolic alkalosis. Short stature is one of the clinical manifestations in these children. Although polyuria, polydipsia, hypokalemia, and salt loss may be responsible for growth retardation, the exact pathogenesis of short stature in Bartter syndrome is not known. CASE DIAGNOSIS AND TREATMENT In this study, we present three children diagnosed as having Bartter syndrome with short stature and growth hormone (GH) deficiency. After recombinant human growth hormone therapy (rhGH), their growth velocities were improved.CONCLUSIONS:
These results indicate that GH deficiency may contribute to short stature in children with Bartter syndrome, and rhGH therapy would be an excellent adjunctive treatment for short children with this syndrome whose condition is resistant to conventional therapies in terms of growth.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Bartter
/
Estatura
/
Hormona de Crecimiento Humana
/
Trastornos del Crecimiento
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Pediatr Nephrol
Asunto de la revista:
NEFROLOGIA
/
PEDIATRIA
Año:
2012
Tipo del documento:
Article