Prepulse inhibition of acoustic startle and the influence of methylphenidate in children with ADHD.
J Atten Disord
; 18(2): 117-22, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-22713361
ABSTRACT
OBJECTIVE:
ADHD is common among children with comorbidity of enuresis. Findings concerning prepulse inhibition (PPI) of startle reflexes are controversial. Although PPI is improved through desamino-arginine vasopressin (dDAVP) in enuresis, some patients also improve concomitant ADHD through dDAVP. This study aims to evaluate whether methylphenidate (MPH) also improves PPI in ADHD.METHOD:
Nineteen ADHD patients were investigated in a prospective, double-blind, crossover study with MPH versus placebo. PPI was measured as a reduction of acoustic startle reflexes. Subgroups of gender, ADHD subtype, and baseline PPI were analyzed.RESULTS:
Median baseline PPI of ADHD patients (51.7%) was below the value of age-matched normal controls (73%, p = .090). MPH showed no improvement in the whole group, or the subgroups gender or subtype. Reduced baseline PPI was significantly improved (22.5%-39.3%, p = .039).CONCLUSION:
Heterogeneity of ADHD is confirmed with a wide range of baseline PPI. The improvement of reduced baseline PPI through MPH suggests impaired sensorimotor gating in this subgroup.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Inhibición Reactiva
/
Trastorno por Déficit de Atención con Hiperactividad
/
Reflejo de Sobresalto
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Estimulantes del Sistema Nervioso Central
/
Metilfenidato
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
Idioma:
En
Revista:
J Atten Disord
Asunto de la revista:
PSICOLOGIA
/
PSIQUIATRIA
Año:
2014
Tipo del documento:
Article