Fatal serotonin syndrome precipitated by oxcarbazepine in a patient using an selective serotonin reuptake inhibitor.
Neurologist
; 18(4): 204-5, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22735246
ABSTRACT
Oxcarbazepine, a metabolite of carbamazepine, is used as an antiepileptic, analgesic for neuropathic pain and in the treatment of affective disorders. It has been approved by the Food and Drug Administration for partial seizures in adults as both adjunctive and monotherapy, and as adjunctive therapy in children aged from 2 to 16 years (http//www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4254b_07_05_KP%20OxcarbazepineFDAlabel102005.pdf). We present a case of serotonin syndrome, which was precipitated by this medicine in a patient who had been predisposed by long-term treatment with sertraline, a selective serotonin reuptake inhibitor. This is the first reported fatality due to this drug interaction and only the second case of serotonin syndrome reported with oxcarbazepine. Physicians should consider this risk when prescribing the above combination.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Carbamazepina
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Inhibidores Selectivos de la Recaptación de Serotonina
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Síndrome de la Serotonina
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Sertralina
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Interacciones Farmacológicas
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Analgésicos
Idioma:
En
Revista:
Neurologist
Asunto de la revista:
NEUROLOGIA
Año:
2012
Tipo del documento:
Article