Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss.
Biochemistry (Mosc)
; 77(6): 666-70, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22817467
The influence of the mitochondria-targeted antioxidant SkQR1 on gentamycin-induced nephrotoxicity and ototoxicity has been analyzed. SkQR1 reduces the death of kidney epithelium cells and decreases the severity of renal failure caused by gentamycin application and also lowers the animals' mortality. Treatment with SkQR1 also decreases gentamycin-induced hearing loss. Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Rodaminas
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Plastoquinona
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Insuficiencia Renal
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Pérdida Auditiva
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Antioxidantes
Idioma:
En
Revista:
Biochemistry (Mosc)
Año:
2012
Tipo del documento:
Article