Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T.
Magn Reson Imaging
; 31(2): 163-70, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-22898680
ABSTRACT
Metabolic imaging of hyperpolarized [1-(13)C] pyruvate co-polarized with [(13)C]urea by dynamic nuclear polarization with rapid dissolution is a promising new method for assessing tumor metabolism and perfusion simultaneously in vivo. Novel pulse sequences are required to enable dynamic imaging of multiple (13)C spectral lines with high spatiotemporal resolution. The goal of this study was to investigate a new frequency-specific approach for rapid metabolic imaging of multiple (13)C resonances using the spectral selectivity of steady-state free precession pulse (SSFP) trains. Methods developed in simulations were implemented in a dynamic frequency-cycled balanced SSFP pulse sequence on a 14.1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer.
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Base de datos:
MEDLINE
Asunto principal:
Isótopos de Carbono
/
Imagen por Resonancia Magnética
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Magn Reson Imaging
Año:
2013
Tipo del documento:
Article