Downregulation of CCR5 expression on the peripheral blood CD8+ T cells of southeastern Iranian patients with chronic hepatitis B infection.
Inflammation
; 36(1): 136-40, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-22918850
ABSTRACT
Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8(+) T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8(+) T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5(+)/CD8(+) T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T Citotóxicos
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Virus de la Hepatitis B
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Linfocitos T CD8-positivos
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Hepatitis B Crónica
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Receptores CCR5
País/Región como asunto:
Asia
Idioma:
En
Revista:
Inflammation
Año:
2013
Tipo del documento:
Article