Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine.
J Surg Res
; 182(1): 101-7, 2013 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-22921917
ABSTRACT
BACKGROUND:
Hemorrhage within an intact abdominal cavity remains a leading cause of preventable death on the battlefield. Despite this need, there is no existing closed-cavity animal model to assess new hemostatic agents for the preoperative control of intra-abdominal hemorrhage.METHODS:
We developed a novel, lethal liver injury model in non-coagulopathic swine by strategic placement of two wire loops in the medial liver lobes including the hepatic and portal veins. Distraction resulted in grade V liver laceration with hepato-portal injury, massive bleeding, and severe hypotension. Crystalloid resuscitation was started once mean arterial pressure (MAP) fell below 65 mm Hg. Monitoring continued for up to 180 min.RESULTS:
We demonstrated 90% lethality (9/10) in swine receiving injury and fluid resuscitation, with a mean survival time of 43 min. Previous efforts in our laboratory to develop a consistently lethal swine model of abdominal solid organs, including preemptive anticoagulation, a two-hit injury with controlled hemorrhage prior to liver trauma, and the injury described above without resuscitation, consistently failed to result in lethal injury.CONCLUSION:
This model can be used to screen other interventions for pre hospital control of noncompressible.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vena Porta
/
Hemorragia
/
Venas Hepáticas
/
Hígado
Idioma:
En
Revista:
J Surg Res
Año:
2013
Tipo del documento:
Article