Preaching about the converted: how meiotic gene conversion influences genomic diversity.
Ann N Y Acad Sci
; 1267: 95-102, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22954222
ABSTRACT
Meiotic crossover (CO) recombination involves a reciprocal exchange between homologous chromosomes. COs are often associated with gene conversion at the exchange site where genetic information is unidirectionally transferred from one chromosome to the other. COs and independent assortment of homologous chromosomes contribute significantly to the promotion of genomic diversity. What has not been appreciated is the contribution of another product of meiotic recombination, noncrossovers (NCOs), which result in gene conversion without exchange of flanking markers. Here, we review our comprehensive analysis of recombination at a highly polymorphic mouse hotspot. We found that NCOs make up â¼90% of recombination events. Preferential recombination initiation on one chromosome allowed us to estimate the contribution of CO and NCO gene conversion to transmission distortion, a deviation from Mendelian inheritance in the population. While NCO gene conversion tracts are shorter, and thus have a more punctate effect, their higher frequency translates into an approximately two-fold greater contribution than COs to gene conversion-based allelic shuffling and transmission distortion. We discuss the potential impact of mammalian NCO characteristics on evolution and genomic diversity.
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Base de datos:
MEDLINE
Asunto principal:
Variación Genética
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Genoma Humano
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Conversión Génica
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Meiosis
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
2012
Tipo del documento:
Article