Maternal and offspring dopamine D4 receptor genotypes interact to influence juvenile impulsivity in vervet monkeys.
Psychol Sci
; 23(10): 1099-104, 2012 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-22961771
ABSTRACT
The merging of psychological and genetic methodologies has led to an increasing appreciation of environmental moderators of the relationships between genotype and phenotype. Here we used a nonhuman-primate model to study the moderating effect of the mother's genotype on the association of a dopamine D4 receptor (DRD4) gene polymorphism with juvenile impulsivity, assessed in a standardized social-challenge test. The results showed that juvenile carriers of the rare 5-repeat variant of the exon III 48-base-pair repeat polymorphism scored significantly higher in social impulsivity than juveniles homozygous for the common 6-repeat allele. In addition, juvenile genotype interacted with maternal genotype to influence impulsivity, with the highest rates of impulsivity found in variant offspring with variant mothers. These results highlight the importance of considering the genotype of the parents in studies of early experience and vulnerability genes for impulsivity-related traits.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Conducta Social
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Conducta Animal
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Receptores de Dopamina D4
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Genotipo
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Conducta Impulsiva
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Madres
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Psychol Sci
Asunto de la revista:
PSICOLOGIA
Año:
2012
Tipo del documento:
Article