Design and synthesis of procollagen C-proteinase inhibitors.
Bioorg Med Chem Lett
; 22(24): 7397-401, 2012 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-23134659
Non-peptidic inhibitors of procollagen C-proteinase (PCP) were designed from substrate leads. Compounds were optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties. Compounds 89 and 60 have IC(50) values of 10 and 80 nM, respectively, against PCP; excellent selectivity over MMP's 1, 2, and 9; and activity in cell-based collagen deposition assays.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Inhibidores de Proteasas
/
Diseño de Fármacos
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Proteína Morfogenética Ósea 1
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2012
Tipo del documento:
Article