Xenobiotic sulphation and its variability during inflammation: a factor in adverse drug reactions?
Curr Drug Metab
; 14(3): 361-5, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-23176089
ABSTRACT
The interactions between disease processes and the metabolism of therapeutic drugs have not been systematically investigated. Inflammation, with the presence of pro-inflammatory cytokines, affects Phase 1 metabolism, particularly the activity of the CYP isoforms. Inflammatory factors also alter the activity of some Phase 2 enzymes, particularly the sulphotransferases (SULT isoforms) responsible for drug sulphonation and the enzyme pathway involved in the supply of sulphate for this reaction. Being ill may, therefore, in itself make drug metabolism unpredictable.
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Base de datos:
MEDLINE
Asunto principal:
Sulfatos
/
Xenobióticos
/
Inflamación
Idioma:
En
Revista:
Curr Drug Metab
Asunto de la revista:
METABOLISMO
/
QUIMICA
Año:
2013
Tipo del documento:
Article