Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF.
Physiol Behav
; 109: 69-74, 2013 Jan 17.
Article
en En
| MEDLINE
| ID: mdl-23220362
ABSTRACT
Obesity, high-fat diets, and subsequent type 2 diabetes (T2DM) are associated with cognitive impairment. Moreover, T2DM increases the risk of Alzheimer's disease (AD) and leads to abnormal elevation of brain beta-amyloid levels, one of the hallmarks of AD. The psychoactive alkaloid caffeine has been shown to have therapeutic potential in AD but the central impact of caffeine has not been well-studied in the context of a high-fat diet. Here we investigated the impact of caffeine administration on metabolism and cognitive performance, both in control rats and in rats placed on a high-fat diet. The effects of caffeine were significant caffeine both (i) prevented the weight-gain associated with the high-fat diet and (ii) prevented cognitive impairment. Caffeine did not alter hippocampal metabolism or insulin signaling, likely because the high-fat-fed animals did not develop full-blown diabetes; however, caffeine did prevent or reverse a decrease in hippocampal brain-derived neurotrophic factor (BDNF) seen in high-fat-fed animals. These data confirm that caffeine may serve as a neuroprotective agent against cognitive impairment caused by obesity and/or a high-fat diet. Increased hippocampal BDNF following caffeine administration could explain, at least in part, the effects of caffeine on cognition and metabolism.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Cafeína
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Aumento de Peso
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Trastornos del Conocimiento
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Factor Neurotrófico Derivado del Encéfalo
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Dieta Alta en Grasa
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Hipocampo
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Estimulantes del Sistema Nervioso Central
Tipo de estudio:
Etiology_studies
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Prognostic_studies
Idioma:
En
Revista:
Physiol Behav
Año:
2013
Tipo del documento:
Article