Tumor growth modeling from the perspective of multiphase porous media mechanics.
Mol Cell Biomech
; 9(3): 193-212, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-23285734
ABSTRACT
Multiphase porous media mechanics is used for modeling tumor growth, using governing equations obtained via the thermodynamically constrained averaging theory (TCAT). This approach incorporates the interaction of more phases than legacy tumor growth models. The tumor is treated as a multiphase system composed of an extracellular matrix, tumor cells which may become necrotic depending on nutrient level and pressure, healthy cells and an interstitial fluid which transports nutrients. The governing equations are numerically solved within a Finite Element framework for predicting the growth rate of the tumor mass, and of its individual components, as a function of the initial tumor-to-healthy cell ratio, nutrient concentration, and mechanical strain. Preliminary results are shown.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Matriz Extracelular
/
Modelos Biológicos
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Mol Cell Biomech
Asunto de la revista:
BIOLOGIA MOLECULAR
/
ENGENHARIA BIOMEDICA
Año:
2012
Tipo del documento:
Article