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Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease.
Rembach, Alan; Faux, Noel G; Watt, Andrew D; Pertile, Kelly K; Rumble, Rebecca L; Trounson, Brett O; Fowler, Christopher J; Roberts, Blaine R; Perez, Keyla A; Li, Qiao-Xin; Laws, Simon M; Taddei, Kevin; Rainey-Smith, Stephanie; Robertson, Joanne S; Vandijck, Manu; Vanderstichele, Hugo; Barnham, Kevin J; Ellis, Kathryn A; Szoeke, Cassandra; Macaulay, Lance; Rowe, Christopher C; Villemagne, Victor L; Ames, David; Martins, Ralph N; Bush, Ashley I; Masters, Colin L.
Afiliación
  • Rembach A; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia. Electronic address: a.rembach@unimelb.edu.au.
  • Faux NG; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Watt AD; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Pertile KK; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Rumble RL; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Trounson BO; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Fowler CJ; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Roberts BR; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Perez KA; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Li QX; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Laws SM; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup. Western Australia, Australia.
  • Taddei K; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup. Western Australia, Australia.
  • Rainey-Smith S; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup. Western Australia, Australia.
  • Robertson JS; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Vandijck M; Department of Diagnostic Development, Innogenetics NV, Ghent, Belgium.
  • Vanderstichele H; Department of Diagnostic Development, Innogenetics NV, Ghent, Belgium; Biomarkable, Gent, Belgium.
  • Barnham KJ; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Ellis KA; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia; Department of Psychiatry, St George's Hospital, University of Melbourne, Victoria, Australia; National Ageing Research Institute, Parkville, Victoria, Australia.
  • Szoeke C; Department of Psychiatry, St George's Hospital, University of Melbourne, Victoria, Australia; National Ageing Research Institute, Parkville, Victoria, Australia.
  • Macaulay L; CSIRO Molecular and Health Technologies, Parkville, Victoria, Australia.
  • Rowe CC; Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
  • Villemagne VL; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia; Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
  • Ames D; National Ageing Research Institute, Parkville, Victoria, Australia.
  • Martins RN; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup. Western Australia, Australia.
  • Bush AI; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
  • Masters CL; The Mental Health Research Institute, The University of Melbourne, Victoria, Australia.
Alzheimers Dement ; 10(1): 53-61, 2014 Jan.
Article en En | MEDLINE | ID: mdl-23491263
BACKGROUND: A practical biomarker is required to facilitate the preclinical diagnosis of Alzheimer's disease (AD). METHODS: Plasma amyloid beta (Aß)1-40, Aß1-42, Aßn-40, and Aßn-42 peptides were measured at baseline and after 18 months in 771 participants from the Australian Imaging Biomarkers and Lifestyle (AIBL) study of aging. Aß peptide levels were compared with clinical pathology, neuroimaging and neuropsychological measurements. RESULTS: Although inflammatory and renal function covariates influenced plasma Aß levels significantly, a decrease in Aß1-42/Aß1-40 was observed in patients with AD, and was also inversely correlated with neocortical amyloid burden. During the 18 months, plasma Aß1-42 decreased in subjects with mild cognitive impairment (MCI) and in those transitioning from healthy to MCI. CONCLUSION: Our findings are consistent with a number of published plasma Aß studies and, although the prognostic value of individual measures in any given subject is limited, the diagnostic contribution of plasma Aß may demonstrate utility when combined with a panel of peripheral biomarkers.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Envejecimiento / Péptidos beta-Amiloides / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Alzheimers Dement Año: 2014 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Envejecimiento / Péptidos beta-Amiloides / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Alzheimers Dement Año: 2014 Tipo del documento: Article