Evidence for age-dependent in vivo conformational rearrangement within Aß amyloid deposits.
ACS Chem Biol
; 8(6): 1128-33, 2013.
Article
en En
| MEDLINE
| ID: mdl-23521783
ABSTRACT
Deposition of aggregated Aß peptide in the brain is one of the major hallmarks of Alzheimer's disease. Using a combination of two structurally different, but related, hypersensitive fluorescent amyloid markers, LCOs, reporting on separate ultrastructural elements, we show that conformational rearrangement occurs within Aß plaques of transgenic mouse models as the animals age. This important mechanistic insight should aid the design and evaluation of experiments currently using plaque load as readout.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Envejecimiento
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Péptidos beta-Amiloides
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Placa Amiloide
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Enfermedad de Alzheimer
Idioma:
En
Revista:
ACS Chem Biol
Año:
2013
Tipo del documento:
Article