Novel chitosan derivative for temperature and ultrasound dual-sensitive liposomal microbubble gel.
Carbohydr Polym
; 94(1): 17-23, 2013 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-23544504
ABSTRACT
In this study, a novel liposome-loaded microbubble gel based on N-cholesteryl hemisuccinate-O-sulfate chitosan (NCHOSC) was designed. The structure of the NCHOSC was characterized by FTIR and (1)H NMR. The liposomal microbubble gel based on NCHOSC with a high encapsulation efficiency of curcumin was formed and improved the solubility of curcumin. The diameter of most liposomal microbubble was about 950 nm. The temperature-sensitive CS/GP gel could be formulated at room temperature and would form a gel at body temperature. Simultaneously, the ultrasound-sensitive induced release of curcumin was 85% applying ultrasound. The results of cytotoxicity assay indicated that encapsulated curcumin in Cur-LM or Cur-LM-G was less toxic. The anti-tumor efficacy in vivo suggested that Cur-LM-G by ultrasound suppressed tumor growth most efficiently. These findings have shed some light on the potential NCHOSC material used to liposome-loaded microbubble gel for temperature and ultrasound dual-sensitive drug delivery.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ésteres del Colesterol
/
Curcumina
/
Preparaciones de Acción Retardada
/
Quitosano
/
Antineoplásicos Fitogénicos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
Carbohydr Polym
Año:
2013
Tipo del documento:
Article