Randomized controlled trial: a randomized controlled clinical trial comparing a remineralizing paste with an antibacterial gel to prevent early childhood caries.
Pediatr Dent
; 35(1): 8-12, 2013.
Article
en En
| MEDLINE
| ID: mdl-23635884
ABSTRACT
PURPOSE:
The purpose of this study was to compare twice daily tooth-brushing using 0.304 percent fluoride toothpaste alone with (1) twice daily tooth-brushing plus once daily 10% casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste; and (2) twice daily tooth-brushing plus once daily 0.12% chlorhexidine gel (CHX) for reducing early childhood caries (ECC) and mutans streptococci (MS) colonization.METHODS:
Subjects (n=622) recruited at birth were randomized to receive either CPP-ACP or CHX or no product (study control [SC]). All children were examined at 6, 12, and 18 months old in their homes, and at 24 months old in a community dental clinic.RESULTS:
At 24 months old, the caries incidence was 1% (2/163) in CPP-ACP, 2% (4/180) in CHX, and 2% (3/188) in SC groups. In children who were previously MS colonized at 12 and 18 months old, 0% (0/11) and 5% (3/63), respectively, of the CPP-ACP group remained MS-positive versus 22% (2/9) and 72% (18/25) in CHX and 16% (4/25) and 50% (7/14) in SC groups (P<.001).CONCLUSIONS:
There is insufficient evidence to justify the daily use of casein phosphopeptide-amorphous calcium phosphate or chlorhexidine gel to control early childhood caries.
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Base de datos:
MEDLINE
Asunto principal:
Remineralización Dental
/
Pastas de Dientes
/
Cariostáticos
/
Caries Dental
/
Antiinfecciosos Locales
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
Pediatr Dent
Año:
2013
Tipo del documento:
Article