Studying protein-ligand interactions using X-ray crystallography.
Methods Mol Biol
; 1008: 457-77, 2013.
Article
en En
| MEDLINE
| ID: mdl-23729263
ABSTRACT
X-ray crystallography is a powerful technique for studying protein-ligand interactions. Advances in techniques have meant that it is now possible to routinely determine the structures of ligand complexes in the majority of cases where crystallization conditions and protein structures are already known. Ligand soaking or cocrystallization, together with the potential use of molecular replacement, provides data for determining the structures of a protein in complex with ligands. Furthermore, advances in protein structure model building facilitate automatic ligand fitting to residual electron density in the protein-ligand complex.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Quinazolinas
/
Tamoxifeno
/
Programas Informáticos
/
Receptores ErbB
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Proteínas de Neoplasias
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2013
Tipo del documento:
Article