Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records.
PLoS One
; 8(6): e63481, 2013.
Article
en En
| MEDLINE
| ID: mdl-23762230
ABSTRACT
The feasibility of using imperfectly phenotyped "silver standard" samples identified from electronic medical record diagnoses is considered in genetic association studies when these samples might be combined with an existing set of samples phenotyped with a gold standard technique. An analytic expression is derived for the power of a chi-square test of independence using either research-quality case/control samples alone, or augmented with silver standard data. The subset of the parameter space where inclusion of silver standard samples increases statistical power is identified. A case study of dementia subjects identified from electronic medical records from the Electronic Medical Records and Genomics (eMERGE) network, combined with subjects from two studies specifically targeting dementia, verifies these results.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Polimorfismo de Nucleótido Simple
/
Genómica
/
Demencia
/
Estudio de Asociación del Genoma Completo
/
Registros Electrónicos de Salud
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2013
Tipo del documento:
Article