The effects of nicotine on cone and rod b-wave responses in larval zebrafish.
Vis Neurosci
; 30(4): 141-5, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23809941
ABSTRACT
Acetylcholine is present in and released from starburst amacrine cells in the inner plexiform layer (IPL), but its role in retinal function except, perhaps, in early development, is unclear. Nicotinic acetylcholine receptors are thought to be present on ganglion, amacrine, and bipolar cell processes in the IPL, and it is known that acetylcholine increases the spontaneous and light-evoked responses of retinal ganglion cells. The effects of acetylcholine on bipolar cells are not known, and here we report the effects of nicotine on the b-wave of the electroretinogram in larval zebrafish. The b-wave originates mainly from ON-bipolar cells, and the larval zebrafish retina is cone-dominated. Only small rod responses can be elicited with dim lights in wild-type larval zebrafish retinas, but rod responses can be recorded over a range of intensities in a mutant ( n o optokinetic response f ) fi sh that has no cone function. We fi nd that nicotine strongly enhances cone-driven b-wave response amplitudes but depresses rod driven b-wave response amplitudes without, however, affecting rod- or cone-driven b-wave light sensitivity.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Pez Cebra
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Células Fotorreceptoras Retinianas Bastones
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Células Fotorreceptoras Retinianas Conos
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Agonistas Nicotínicos
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Nicotina
Idioma:
En
Revista:
Vis Neurosci
Asunto de la revista:
NEUROLOGIA
/
OFTALMOLOGIA
Año:
2013
Tipo del documento:
Article