Two ENU-induced alleles of Atp2b2 cause deafness in mice.
PLoS One
; 8(6): e67479, 2013.
Article
en En
| MEDLINE
| ID: mdl-23826306
ABSTRACT
Over 120 loci are known to cause inherited hearing loss in humans. The deafness gene has been identified for only half of these loci. With the aim of identifying some of the remaining deafness genes, we performed an ethylnitrosourea mutagenesis screen for deaf mice. We isolated two mutants with semi-dominant hearing loss, Deaf11 and Deaf13. Both contained causative mutations in Atp2b2, which encodes the plasma membrane calcium ATPase 2. The Atp2b2 (Deaf11) mutation leads to a p. I1023S substitution in the tenth transmembrane domain. The Atp2b2 (Deaf13) mutation leads to a p. R561S substitution in the catalytic core. Mice homozygous for these mutations display profound hearing loss. Heterozygotes display mild to moderate, progressive hearing loss.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sordera
/
Alelos
/
ATPasas Transportadoras de Calcio de la Membrana Plasmática
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2013
Tipo del documento:
Article