Tailoring chronic pain treatments for the elderly: are we prepared for the challenge?
Drug Discov Today
; 19(1): 8-17, 2014 Jan.
Article
en En
| MEDLINE
| ID: mdl-24001595
ABSTRACT
Chronic pain is increasingly recognized as a disease and accounts for substantial suffering and disability worldwide. The aging 'baby-boomer' generation is creating a tsunami of elderly patients (>65 years old) for global healthcare systems (between 2010 and 2030). The phenotypic expression of chronic pain in the elderly can be influenced by co-morbid diseases (e.g. diabetes, cancer, depression, Alzheimer's disease, etc.), changes in physiological competency (e.g. drug metabolism/elimination) or cognitive reserve. Will a shift in the drug discovery paradigm be required to improve efficacy, side-effects or positively impact quality of life (QoL) in the elderly with chronic pain? This review highlights a number of potential pitfalls that should be considered when delivering valued pain relief medicines tailored for the elderly.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Esperanza de Vida
/
Dolor Crónico
/
Manejo del Dolor
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Drug Discov Today
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2014
Tipo del documento:
Article