An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state.
Science
; 341(6152): 1404-8, 2013 Sep 20.
Article
en En
| MEDLINE
| ID: mdl-24052309
ABSTRACT
An appropriate balance in glycosylation of proteoglycans is crucial for their ability to regulate animal development. Here, we report that the Caenorhabditis elegans microRNA mir-79, an ortholog of mammalian miR-9, controls sugar-chain homeostasis by targeting two proteins in the proteoglycan biosynthetic pathway a chondroitin synthase (SQV-5; squashed vulva-5) and a uridine 5'-diphosphate-sugar transporter (SQV-7). Loss of mir-79 causes neurodevelopmental defects through SQV-5 and SQV-7 dysregulation in the epidermis. This results in a partial shutdown of heparan sulfate biosynthesis that impinges on a LON-2/glypican pathway and disrupts neuronal migration. Our results identify a regulatory axis controlled by a conserved microRNA that maintains proteoglycan homeostasis in cells.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Movimiento Celular
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Caenorhabditis elegans
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Proteoglicanos de Heparán Sulfato
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MicroARNs
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Epidermis
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Neuronas
Idioma:
En
Revista:
Science
Año:
2013
Tipo del documento:
Article