Adapting social neuroscience measures for schizophrenia clinical trials, Part 1: ferrying paradigms across perilous waters.
Schizophr Bull
; 39(6): 1192-200, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-24072811
ABSTRACT
Social cognitive impairment is prominent in schizophrenia, and it is closely related to functional outcome. Partly for these reasons, it has rapidly become a target for both training and psychopharmacological interventions. However, there is a paucity of reliable and valid social cognitive endpoints that can be used to evaluate treatment response in clinical trials. Also, clinical studies in schizophrenia have benefited rather little from the surge of activity and knowledge in nonclinical social neuroscience. The National Institute of Mental Health-sponsored study, "Social Cognition and Functioning in Schizophrenia" (SCAF), attempted to address this translational challenge by selecting paradigms from social neuroscience that could be adapted for use in schizophrenia. The project also evaluated the psychometric properties and external validity of the tasks to determine their suitability for multisite clinical trials. This first article in the theme section presents the goals, conceptual background, and rationale for the SCAF project.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Trastorno de la Conducta Social
/
Neurociencias
/
Ensayos Clínicos como Asunto
/
Trastornos del Conocimiento
Tipo de estudio:
Diagnostic_studies
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Schizophr Bull
Año:
2013
Tipo del documento:
Article