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Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR.
Munigunti, Ranjith; Becker, Katja; Brun, Reto; Calderón, Angela I.
Afiliación
  • Munigunti R; Department of Pharmacal Sciences, 4306 Walker Building, Auburn University, Auburn, AL, USA.
Nat Prod Commun ; 8(8): 1135-6, 2013 Aug.
Article en En | MEDLINE | ID: mdl-24079187
In our study, the binding affinities of selected natural products towards PfTrxR, PfGR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay. The in vitro antimalarial activity and cytotoxicity of these ligands were also determined. Catharanthine, 11-(OH)-coronaridine, hernagine, vobasine and hispolone displayed antiplasmodial activity against PfK1 (IC50 = 0.996-3.63 microg/mL).
Asunto(s)
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Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Reductasa de Tiorredoxina-Disulfuro / Productos Biológicos / Glutatión Reductasa / Antiprotozoarios Idioma: En Revista: Nat Prod Commun Asunto de la revista: BOTANICA / FARMACOLOGIA / QUIMICA Año: 2013 Tipo del documento: Article
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Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Reductasa de Tiorredoxina-Disulfuro / Productos Biológicos / Glutatión Reductasa / Antiprotozoarios Idioma: En Revista: Nat Prod Commun Asunto de la revista: BOTANICA / FARMACOLOGIA / QUIMICA Año: 2013 Tipo del documento: Article