Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR.
Nat Prod Commun
; 8(8): 1135-6, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-24079187
In our study, the binding affinities of selected natural products towards PfTrxR, PfGR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay. The in vitro antimalarial activity and cytotoxicity of these ligands were also determined. Catharanthine, 11-(OH)-coronaridine, hernagine, vobasine and hispolone displayed antiplasmodial activity against PfK1 (IC50 = 0.996-3.63 microg/mL).
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Base de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Reductasa de Tiorredoxina-Disulfuro
/
Productos Biológicos
/
Glutatión Reductasa
/
Antiprotozoarios
Idioma:
En
Revista:
Nat Prod Commun
Asunto de la revista:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Año:
2013
Tipo del documento:
Article