[Relationship between polymorphisms of tumor necrosis factor alpha gene and primary myelodysplastic syndromes].
Zhonghua Xue Ye Xue Za Zhi
; 34(10): 873-6, 2013 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-24171962
ABSTRACT
OBJECTIVE:
To investigate the association of single nucleus polymorphisms(SNP)of tumor necrosis factor alpha (TNF-α) gene (-308 G>A and -238 G>A genotypes) with susceptibility to primary myelodysplastic syndromes (MDS).METHODS:
Two SNPs (TNF-α-308 G>A,TNF-α-238 G>A) of TNF-α gene were detected by Taqman probes in 341 MDS patients and 365 unrelated-healthy controls.RESULTS:
Compared to healthy controls, the frequency of TNF-α-308 AA+AG genotype and A allele increased (18% vs 10%, P=0.015, 9% vs 5%, P=0.021, respectively) in refractory cytopenia with multilineage dysplasia (RCMD) patients. There was no correlation of TNF-α-308 G>A genotype and allele frequency between MDS and controls. No difference in the genotype and allele frequency of TNF-α-238 G>A were found between controls and MDS or the subtypes of MDS (P>0.05). We did not find any linkage between plasma level of TNF-α and TNF-α-308 G>A or TNF-α-238 G>A genotype. Statistic differences were observed between platelet count[58(1-611)×109/L vs 90(7-352)×109/L]and bone marrow blasts in MDS patients carrying TNF-α-308 G>A GG and AA+AG genotype (P=0.024, 0.019, respectively).CONCLUSION:
TNF-α-308 G>A polymorphism was correlated with susceptibility to MDS-RCMD.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Síndromes Mielodisplásicos
/
Factor de Necrosis Tumoral alfa
/
Polimorfismo de Nucleótido Simple
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
Zh
Revista:
Zhonghua Xue Ye Xue Za Zhi
Año:
2013
Tipo del documento:
Article