Increased cerebrospinal fluid tau levels in logopenic variant of Alzheimer's disease.
J Alzheimers Dis
; 39(3): 611-6, 2014.
Article
en En
| MEDLINE
| ID: mdl-24217280
ABSTRACT
BACKGROUND:
Patients with logopenic variant of primary progressive aphasia (lvPPA) display neuropathological differences from typical amnestic Alzheimer's disease (AD).OBJECTIVE:
The aim of the study was to compare cerebrospinal fluid (CSF) biomarker levels between patients with lvPPA due to AD (lvPPA-AD), non-logopenic forms of AD (nlAD), and amnestic mild cognitive impairment due to AD (aMCI-AD).METHODS:
CSF biomarker concentrations were assessed in 124 patients divided into three groups matched for age, level of education, center, and disease duration lvPPA-AD (n = 30), nlAD (n = 67). and aMCI-AD (n = 27).RESULTS:
p-Tau181 levels were higher in the lvPPA-AD group than in the aMCI-AD group (p < 0.05). Total tau levels were higher in the lvPPA-AD group versus those in the nlAD (p < 0.05) and aMCI-AD (p < 0.001) groups.CONCLUSIONS:
These results suggest a more pronounced involvement of a taupathy in lvPPA-AD compared to aMCI-AD and a more important neuronal death in lvPPA-AD than in nlAD or aMCI-AD.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Proteínas tau
/
Afasia Progresiva Primaria
/
Enfermedad de Alzheimer
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2014
Tipo del documento:
Article