The recovery of bladder epithelial hyperplasia caused by a melamine diet-induced bladder calculus in mice.
Food Chem Toxicol
; 64: 378-82, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24355167
ABSTRACT
Applying a model of bladder epithelial hyperplasia (BEH) caused by melamine-induced bladder calculus (BC), the recovery of BEH after melamine withdrawal was investigated. One experiment, comprising untreated, melamine and recovery groups, was conducted in Balb/c mice. Each group included 4 subgroups. Mice were fed normal-diet in untreated or a melamine-diet in other groups. The melamine-diet was then substituted with normal-diet in recovery group. Both of BC and BEH were observed after 14 and 56 days of melamine-diet. The BC is relatively uniform at the same melamine-diet durations. The BEH was diffuse with many mitotic figures, 4-7 rows of nuclei, and well-defined umbrella/intermediate cells. No marked differences in BEH degree were observed in the two different melamine-diet durations. On 4-42 days after melamine withdrawal, BC was not found, as the progressive regression with complete regression of BEH was observed, along with well-defined ageing/apoptotic cells in the superficial regions of BEH regression tissue. Conclusion, the melamine-induced BEH is relatively uniform, may be self-limiting in rows of nuclei, and can return to normal. Melamine withdrawal duration is critical for the BEH regression. Tissue of the BEH and its regression is ideal for exploring the renewal as well as growth biology of mammalian urothelium.
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Base de datos:
MEDLINE
Asunto principal:
Triazinas
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Vejiga Urinaria
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Cálculos Urinarios
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Hiperplasia
Idioma:
En
Revista:
Food Chem Toxicol
Año:
2014
Tipo del documento:
Article