Iron-refractory microcytic anemia as the presenting feature of unicentric Castleman disease in children.
J Pediatr
; 164(4): 928-30, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24367988
ABSTRACT
Chronic, iron-refractory, microcytic anemia can be a diagnostic and therapeutic challenge. We report the cases of 2 children with occult, unicentric Castleman disease whose primary presenting feature was a chronic, unexplained, iron-refractory, microcytic anemia. Diagnosis was delayed because neither child had palpable lymphadenopathy and the lymphoproliferation was intra-abdominal. Surgical resection cured the anemia and the Castleman disease. A diagnostic clue to Castleman disease is an elevated concentration of interleukin-6 in blood, which causes anemia by inducing the expression of the iron-regulatory hormone hepcidin.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Castleman
/
Anemia Ferropénica
Idioma:
En
Revista:
J Pediatr
Año:
2014
Tipo del documento:
Article