[Determination of 2, 4-toluenediamine in urine by gas chromatography].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 31(12): 939-40, 2013 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-24370370
ABSTRACT
OBJECTIVE:
To establish a method for determining the content of 2,4-toluenediamine, a urinary metabolite of toluene diisocyanate, by gas chromatography.METHODS:
Urine samples were collected, and acidification, extraction, derivatization, separation with a capillary column, and detection with an electron capture detector were performed. The target compound was qualified by retention time and quantified by peak area.RESULTS:
The concentration of 2, 4-toluenediamine showed a linear relationship with peak area within 0.0â¼40 ng/ml, with a correlation coefficient 0.9995; the limit of detection was 0.44 ng/ml, the lower limit of quantification was 1.47 ng/ml, the relative standard deviation was 1.85%â¼4.05%; the recovery rate was 97.98%â¼99.28%.CONCLUSION:
The method has the advantages of high sensitivity and high accuracy and can be used for determination of 2, 4-toluenediamine in urine.
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Base de datos:
MEDLINE
Asunto principal:
Fenilendiaminas
/
Cromatografía de Gases
/
Exposición Profesional
Idioma:
Zh
Revista:
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
Asunto de la revista:
MEDICINA OCUPACIONAL
Año:
2013
Tipo del documento:
Article