Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death.

Okabe, Akishi; Urano, Yasuomi; Itoh, Sayoko; Suda, Naoto; Kotani, Rina; Nishimura, Yuki; Saito, Yoshiro; Noguchi, Noriko

Okabe, Akishi; Urano, Yasuomi; Itoh, Sayoko; Suda, Naoto; Kotani, Rina; Nishimura, Yuki; Saito, Yoshiro; Noguchi, Noriko.

Afiliación

Okabe A; Systems Life Sciences, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.
Urano Y; Systems Life Sciences, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.
Itoh S; Systems Life Sciences, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.
Suda N; Systems Life Sciences, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.
Kotani R; Systems Life Sciences, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.
Nishimura Y; Systems Life Sciences, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.
Saito Y; Systems Life Sciences, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.
Noguchi N; Systems Life Sciences, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.

Redox Biol ; 2: 28-35, 2013.

Article en En | MEDLINE | ID: mdl-24371802

Asunto(s)

Apoptosis/efectos de los fármacos; Hidroxicolesteroles/farmacología; Cetocolesteroles/farmacología; Receptores Nucleares Huérfanos/metabolismo; Transportador 1 de Casete de Unión a ATP/antagonistas & inhibidores; Transportador 1 de Casete de Unión a ATP/genética; Transportador 1 de Casete de Unión a ATP/metabolismo; Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 1; Transportadoras de Casetes de Unión a ATP/antagonistas & inhibidores; Transportadoras de Casetes de Unión a ATP/genética; Transportadoras de Casetes de Unión a ATP/metabolismo; Diferenciación Celular/efectos de los fármacos; Línea Celular Tumoral; Humanos; Receptores X del Hígado; Neuronas/citología; Neuronas/efectos de los fármacos; Receptores Nucleares Huérfanos/antagonistas & inhibidores; Receptores Nucleares Huérfanos/genética; Interferencia de ARN; ARN Interferente Pequeño/metabolismo; Transducción de Señal/efectos de los fármacos; Regulación hacia Arriba/efectos de los fármacos

Palabras clave

24S-hydroxycholesterol; 24SOHC, 24S-hydroxycholesterol; 7-ketocholesterol; 7KC, 7-ketocholesterol; 9cRA, 9-cis retinoic acid; ABCA1, ATP-binding cassette transporter A1; ABCG1, ATP-binding cassette transporter G1; AD, Alzheimer's disease; ATP-binding cassette transporter G1; Adaptive responses; CYP46A1, cholesterol 24-hydroxylase; Cell death; FITC, fluorescein isothiocyanate; HDL, high-density lipoprotein; LDH, lactate dehydrogenase; LXR, liver X receptor; Liver X receptor; MAP2, microtubule-associated protein 2; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NC, negative control; PI, propidium iodide; RXR, retinoid X receptor; atRA, all-trans retinoic acid

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Apoptosis / Receptores Nucleares Huérfanos / Hidroxicolesteroles / Cetocolesteroles Idioma: En Revista: Redox Biol Año: 2013 Tipo del documento: Article

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