[Nuclear magnetic resonance based metabolic phenotyping for patient evaluations in operating rooms and intensive care units]. / Phénotypage métabolique par résonance magnétique nucléaire pour l'évaluation périopératoire et en réanimation.
Ann Fr Anesth Reanim
; 33(3): 167-75, 2014 Mar.
Article
en Fr
| MEDLINE
| ID: mdl-24456616
ABSTRACT
Metabolic phenotyping consists in the identification of subtle and coordinated metabolic variations associated with various pathophysiological stimuli. Different analytical methods, such as nuclear magnetic resonance, allow the simultaneous quantification of a large number of metabolites. Statistical analyses of these spectra thus lead to the discrimination between samples and the identification of a metabolic phenotype corresponding to the effect under study. This approach allows the extraction of candidate biomarkers and the recovery of perturbed metabolic networks, driving to the generation of biochemical hypotheses (pathophysiological mechanisms, diagnostic tests, therapeutic targets
). Metabolic phenotyping could be useful in anaesthesiology and intensive care medicine for the evaluation, monitoring or diagnosis of life-threatening situations, to optimise patient managements. This review introduces the physical and statistical fundamentals of NMR-based metabolic phenotyping, describes the work already achieved by this approach in anaesthesiology and intensive care medicine. Finally, potential areas of interest are discussed for the perioperative and intensive management of patients, from newborns to adults.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Espectroscopía de Resonancia Magnética
/
Monitoreo Intraoperatorio
/
Cuidados Críticos
/
Metabolismo
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Idioma:
Fr
Revista:
Ann Fr Anesth Reanim
Año:
2014
Tipo del documento:
Article