Your browser doesn't support javascript.
loading
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Waterfield, Michael; Khan, Imran S; Cortez, Jessica T; Fan, Una; Metzger, Todd; Greer, Alexandra; Fasano, Kayla; Martinez-Llordella, Marc; Pollack, Joshua L; Erle, David J; Su, Maureen; Anderson, Mark S.
Afiliación
  • Waterfield M; 1] Diabetes Center, University of California San Francisco, San Francisco, California, USA. [2] Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.
  • Khan IS; Diabetes Center, University of California San Francisco, San Francisco, California, USA.
  • Cortez JT; Diabetes Center, University of California San Francisco, San Francisco, California, USA.
  • Fan U; Diabetes Center, University of California San Francisco, San Francisco, California, USA.
  • Metzger T; Diabetes Center, University of California San Francisco, San Francisco, California, USA.
  • Greer A; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, California, USA.
  • Fasano K; Diabetes Center, University of California San Francisco, San Francisco, California, USA.
  • Martinez-Llordella M; Department of Liver Sciences, Division of Transplantation Immunology & Mucosal Biology, Institute of Liver Studies, King's College London, London, UK.
  • Pollack JL; Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Erle DJ; Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Su M; Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Anderson MS; 1] Diabetes Center, University of California San Francisco, San Francisco, California, USA. [2] Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Nat Immunol ; 15(3): 258-65, 2014 Mar.
Article en En | MEDLINE | ID: mdl-24464130
ABSTRACT
The maintenance of immunological tolerance requires the deletion of self-reactive T cells in the thymus. The expression of genes encoding tissue-specific antigens (TSAs) by thymic epithelial cells is critical for this process and depends on activity of the transcriptional regulator Aire; however, the molecular mechanisms Aire uses to target loci encoding TSAs are unknown. Here we identified two Aire-interacting proteins known to be involved in gene repression, ATF7ip and MBD1, that were required for Aire's targeting of loci encoding TSAs. Moreover, Mbd1(-/-) mice developed pathological autoimmunity and had a defect in Aire-dependent thymic expression of genes encoding TSAs, which underscores the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Factores de Transcripción / Regulación de la Expresión Génica / Proteínas de Unión al ADN / Tolerancia Central / Tolerancia Inmunológica Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2014 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Factores de Transcripción / Regulación de la Expresión Génica / Proteínas de Unión al ADN / Tolerancia Central / Tolerancia Inmunológica Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2014 Tipo del documento: Article