Polycystic ovary syndrome and low-grade inflammation with special reference to YKL-40.
Gynecol Endocrinol
; 30(4): 311-5, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24471491
ABSTRACT
OBJECTIVE:
To evaluate the plasma level of YKL-40 in a Danish polycystic ovary syndrome (PCOS) population and to investigate whether YKL-40 is associated with CVD risk factors such as waist circumference, body mass index (BMI), insulin resistance (IR), fasting glucose, fasting insulin, blood lipids and CRP.DESIGN:
Cross-sectional study.SETTING:
Gynecological clinics at three Danish University Hospitals. PATIENTS One hundred seventy-one premenopausal women with PCOS recruited consecutively from April 2010 to February 2012. PCOS was diagnosed according to the Rotterdam criteria. MAIN OUTCOMEMEASURES:
Plasma level of YKL-40 in four phenotypes of PCOS defined by BMI and IR.RESULTS:
No statistically significant difference was observed in the plasma level of YKL-40 across the four BMI/IR-phenotypes. Positive associations were observed between YKL-40 and BMI, total and free testosterone, triglycerides, and CRP. Total and free testosterone were independent predictors of YKL-40.CONCLUSION:
YKL-40, the marker of low-grade inflammation is not increased in women with PCOS.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Síndrome del Ovario Poliquístico
/
Adipoquinas
/
Inflamación
/
Lectinas
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
Gynecol Endocrinol
Asunto de la revista:
ENDOCRINOLOGIA
/
GINECOLOGIA
Año:
2014
Tipo del documento:
Article