Management of bleeding in severe factor V deficiency with a factor V inhibitor.
Vox Sang
; 107(1): 97-9, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24517203
ABSTRACT
Factor V (FV) inhibitor arises rarely after using fresh frozen plasma (FFP) to treat inherited FV deficiency and is often a real therapeutic challenge. Here, we report a patient with a severe FV deficiency who developed such an inhibitor and was then treated with recombinant activated FVII (rFVIIa) and platelet concentrates (PC). Monitoring was assessed by thrombin generation assay (TGA). PC were more effective than rFVIIa in treating bleeding, but there was no correlation between the TGA results and clinical efficacy.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Factor V
/
Factor VIIa
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Deficiencia del Factor V
/
Hemorragia
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Vox Sang
Año:
2014
Tipo del documento:
Article