Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults.
Clin Endocrinol (Oxf)
; 81(3): 458-66, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-24628365
ABSTRACT
OBJECTIVE:
Redox status and inflammation are important in the pathophysiology of numerous chronic diseases. Epidemiological studies have linked vitamin D status to a number of chronic diseases. We aimed to examine the relationships between serum 25-hydroxyvitamin D [25(OH)D] and circulating thiol/disulphide redox status and biomarkers of inflammation.DESIGN:
This was a cross-sectional study of N = 693 adults (449 females, 244 males) in an apparently healthy, working cohort in Atlanta, GA. Plasma glutathione (GSH), cysteine (Cys) and their associated disulphides were determined with high-performance liquid chromatography, and their redox potentials (Eh GSSG and Eh CySS) were calculated using the Nernst equation. Serum inflammatory markers included interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-α, assayed on a multiplex platform, and C-reactive protein (CRP), assayed commercially. Relationships were assessed with multiple linear regression analyses.RESULTS:
Serum 25(OH)D was positively associated with plasma GSH (ß ± SE 0·002 ± 0·0004) and negatively associated with plasma Eh GSSG (ß ± SE -0·06 ± 0·01) and Cys (ß ± SE -0·01 ± 0·003) (P < 0·001 for all); statistical significance remained after adjusting for age, gender, race, percentage body fat and traditional cardiovascular risk factors (P = 0·01-0·02). The inverse relationship between serum 25(OH)D and CRP was confounded by percentage body fat, and full adjustment for covariates attenuated serum 25(OH)D relationships with other inflammatory markers to nonstatistical significance.CONCLUSIONS:
Serum 25(OH)D concentrations were independently associated with major plasma thiol/disulphide redox systems, suggesting that vitamin D status may be involved in redox-mediated pathophysiology.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vitamina D
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Cisteína
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Glutatión
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Año:
2014
Tipo del documento:
Article