Synthesis and antimetastatic effects of E-salignone amide derivatives.
Drug Dev Res
; 75(2): 76-87, 2014 Mar.
Article
en En
| MEDLINE
| ID: mdl-24648170
ABSTRACT
The preparation of novel E-salignone derivatives and their biological evaluation as potential antimetastatic agents is described. The E-salignone amide derivatives were prepared from epiandrosterone and androsterone, and characterized by analytical (1) H NMR, (13) C NMR, and mass spectrometry. The derivatives were evaluated for antimetastatic activity in MDA-MB-231 cells by using a transwell assay. Comparing with the positive control, LY294002, compounds 19b, 19d, and 19e exhibited significant inhibitory effects on the EGF-induced invasion of MB-MDA-231 cells. Moreover, compound 19b also had antimigration effects in wound-healing assay. Compound 19b may represent a novel antimetastatic agent for treating breast cancer.
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Base de datos:
MEDLINE
Asunto principal:
Pregnenos
/
Neoplasias de la Mama
/
Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Drug Dev Res
Año:
2014
Tipo del documento:
Article