Glucose-6-phosphate dehydrogenase--beyond the realm of red cell biology.
Free Radic Res
; 48(9): 1028-48, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-24720642
Glucose-6-phosphate dehydrogenase (G6PD) is critical to the maintenance of NADPH pool and redox homeostasis. Conventionally, G6PD deficiency has been associated with hemolytic disorders. Most biochemical variants were identified and characterized at molecular level. Recently, a number of studies have shone light on the roles of G6PD in aspects of physiology other than erythrocytic pathophysiology. G6PD deficiency alters the redox homeostasis, and affects dysfunctional cell growth and signaling, anomalous embryonic development, and altered susceptibility to infection. The present article gives a brief review of basic science and clinical findings about G6PD, and covers the latest development in the field. Moreover, how G6PD status alters the susceptibility of the affected individuals to certain degenerative diseases is also discussed.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Glucosafosfato Deshidrogenasa
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Free Radic Res
Asunto de la revista:
BIOQUIMICA
Año:
2014
Tipo del documento:
Article