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Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors.
Winters, Michael P; Subasinghe, Nalin; Wall, Mark; Beck, Edward; Brandt, Michael R; Finley, Michael F A; Liu, Yi; Lubin, Mary Lou; Neeper, Michael P; Qin, Ning; Flores, Christopher M; Sui, Zhihua.
Afiliación
  • Winters MP; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA. Electronic address: mwinter4@its.jnj.com.
  • Subasinghe N; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
  • Wall M; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
  • Beck E; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
  • Brandt MR; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
  • Finley MF; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
  • Liu Y; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
  • Lubin ML; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
  • Neeper MP; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
  • Qin N; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
  • Flores CM; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
  • Sui Z; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
Bioorg Med Chem Lett ; 24(9): 2057-61, 2014 May 01.
Article en En | MEDLINE | ID: mdl-24726803
A novel series of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles were investigated as N-type calcium channel blockers (Cav2.2 channels), a chronic pain target. One compound was active in vivo in the rat CFA pain model.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazoles / Bloqueadores de los Canales de Calcio / Canales de Calcio Tipo N / Analgésicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazoles / Bloqueadores de los Canales de Calcio / Canales de Calcio Tipo N / Analgésicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article