Myocardial protection in donor heart preservation: a comparison between Bretschneider's histidine-tryptophan-ketoglutarate solution and cold blood cardioplegia.
Transplant Proc
; 46(4): 1077-81, 2014 May.
Article
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| MEDLINE
| ID: mdl-24815133
ABSTRACT
BACKGROUND:
Optimal myocardial protection for donated hearts is crucial to improve outcomes of heart transplantation and reduce morbidity and mortality. This study aimed to compare the efficacy of myocardial protection using single dose of Bretschneider's histidine-tryptophan-ketoglutarate (HTK) solution and repeated doses of cold blood cardioplegia (CBC) in donor heart preservation.METHODS:
Sixty-seven patients undergoing heart transplantation in Tri-Service General Hospital, Taipei, Taiwan between 2002 and 2012 were enrolled in this study. Patients were divided into an HTK group and a CBC group based on the preservation solution used to protect the donated hearts. The perioperative variables and postoperative outcomes were retrospectively reviewed.RESULTS:
There were no statistic differences about demographic data in donors and recipients between the 2 groups. There were no significant differences in postoperative cardiac enzymes, hemodynamic data, length of stay in intensive care, or 30-day mortality between the groups. The HTK group showed a trend of shorter pumping time (P = .091). Multivariate analyses reveal that the HTK group had higher postoperative inotropic score (P < .001) and shorter pumping time (P = .02).CONCLUSIONS:
Single dose of Bretschneider's HTK solution could effectively reduce pumping time and afford similar myocardial protection compared with repeated doses of CBC in the preservation of donated hearts.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Preservación de Órganos
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Soluciones Cardiopléjicas
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Daño por Reperfusión Miocárdica
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Trasplante de Corazón
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Frío
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Soluciones Preservantes de Órganos
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Recolección de Tejidos y Órganos
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Paro Cardíaco Inducido
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Insuficiencia Cardíaca
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Transplant Proc
Año:
2014
Tipo del documento:
Article