The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4âº T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs.

Commandeur, Susanna; van den Eeden, Susan J F; Dijkman, Karin; Clark, Simon O; van Meijgaarden, Krista E; Wilson, Louis; Franken, Kees L M C; Williams, Ann; Christensen, Dennis; Ottenhoff, Tom H M; Geluk, Annemieke

The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4âº T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs.

Commandeur, Susanna; van den Eeden, Susan J F; Dijkman, Karin; Clark, Simon O; van Meijgaarden, Krista E; Wilson, Louis; Franken, Kees L M C; Williams, Ann; Christensen, Dennis; Ottenhoff, Tom H M; Geluk, Annemieke.

Afiliación

Commandeur S; Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands.
van den Eeden SJ; Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands.
Dijkman K; Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands.
Clark SO; Public Health England, Microbiology Services, Porton Down, Salisbury, Wiltshire, United Kingdom.
van Meijgaarden KE; Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands.
Wilson L; Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands.
Franken KL; Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands.
Williams A; Public Health England, Microbiology Services, Porton Down, Salisbury, Wiltshire, United Kingdom.
Christensen D; Statens Serum Institut, Copenhagen, Denmark.
Ottenhoff TH; Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands.
Geluk A; Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands. Electronic address: a.geluk@lumc.nl.

Vaccine ; 32(29): 3580-8, 2014 Jun 17.

Article en En | MEDLINE | ID: mdl-24837764

Asunto(s)

Antígenos Bacterianos/inmunología; Linfocitos T CD4-Positivos/inmunología; Vacunas contra la Tuberculosis/inmunología; Adyuvantes Inmunológicos/administración & dosificación; Animales; Proteínas Bacterianas/inmunología; Epítopos de Linfocito T/inmunología; Femenino; Cobayas; Antígeno HLA-DR3/genética; Interferón gamma/inmunología; Ligandos; Ratones Transgénicos; Mycobacterium tuberculosis/inmunología; Proteínas Recombinantes/inmunología; Proteínas Represoras/inmunología; Receptores Toll-Like/inmunología; Vacunas de Subunidad/inmunología

Palabras clave

HLA-DR3; IVE-TB antigen; Infection-specific; Mtb; Rv2034; TB vaccine

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Vacunas contra la Tuberculosis / Antígenos Bacterianos Tipo de estudio: Prognostic_studies Idioma: En Revista: Vaccine Año: 2014 Tipo del documento: Article

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