The influence of comorbid conditions on racial disparities in endometrial cancer survival.
Am J Obstet Gynecol
; 211(6): 627.e1-9, 2014 Dec.
Article
en En
| MEDLINE
| ID: mdl-24954655
ABSTRACT
OBJECTIVE:
There are known disparities in endometrial cancer survival with black women who experience a greater risk of death compared with white women. The purpose of this investigation was to evaluate the role of comorbid conditions as modifiers of endometrial cancer survival by race. STUDYDESIGN:
Two hundred seventy-one black women and 356 white women who had been diagnosed with endometrial cancer from 1990-2005 were identified from a large urban integrated health center. A retrospective chart review was conducted to gather information on comorbid conditions and other known demographic and clinical predictors of survival.RESULTS:
Black women experienced a higher hazard of death from any cause (hazard ratio [HR] 1.51; 95% confidence interval [CI], 1.22-1.87) and from endometrial cancer (HR, 2.42; 95% CI, 1.63-3.60). After adjustment for known clinical prognostic factors and comorbid conditions, the hazard of death for black women was elevated but no longer statistically significant for overall survival (HR, 1.22; 95% CI, 0.94-1.57), and the hazard of death from endometrial cancer remained significantly increased (HR, 2.27; 95% CI, 1.39-3.68). Both black and white women with a history of hypertension experienced a lower hazard of death from endometrial cancer (HR, 0.47; 95% CI, 0.23-0.98; and HR, 0.35; 95% CI, 0.19-0.67, respectively).CONCLUSION:
The higher prevalence of comorbid conditions among black women does not explain fully the racial disparities that are seen in endometrial cancer survival. The association between hypertension and a lower hazard of death from endometrial cancer is intriguing, and further investigation into the underlying mechanism is needed.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Negro o Afroamericano
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Adenocarcinoma
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Neoplasias Endometriales
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Población Blanca
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Diabetes Mellitus
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Hipertensión
/
Obesidad
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
2014
Tipo del documento:
Article