Synthesis and in silico studies of pyrrolidine sulfonamide based dipeptides as ß-gluscosidase inhibitors.
Ann Pharm Fr
; 72(4): 256-66, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24997887
ABSTRACT
A series of novel pyrrolidine sulfonamide derivatives were designed, synthesized and screened in silico for their ß-gluscosidase inhibitory activity. The results showed that the pyrrolidine derivatives exhibited moderate inhibitory activity against human ß-gluscosidases inhibitors. The structure-activity relationships were also briefly discussed. The studies indicated that compounds of Series B with imidazole sulfonyl group were the most potent inhibitors compared to the other compounds under investigation.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Pirrolidinas
/
Sulfonamidas
/
Beta-Glucosidasa
/
Dipéptidos
/
Inhibidores Enzimáticos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Ann Pharm Fr
Año:
2014
Tipo del documento:
Article