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Overexpression of PPARγ specifically in pancreatic ß-cells exacerbates obesity-induced glucose intolerance, reduces ß-cell mass, and alters islet lipid metabolism in male mice.
Hogh, K-Lynn N; Craig, Michael N; Uy, Christopher E; Nygren, Heli; Asadi, Ali; Speck, Madeline; Fraser, Jordie D; Rudecki, Alexander P; Baker, Robert K; Oresic, Matej; Gray, Sarah L.
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  • Hogh KL; Northern Medical Program (K.N.H., M.N.C., C.E.U., J.D.F., A.P.R., S.L.G.), University of Northern British Columbia, Prince George, British Columbia, Canada V2N 4Z9; Department of Cellular and Physiological Sciences and Faculty of Medicine (A.A., R.K.B.), University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4; VTT Technical Research Centre of Finland (H.N., M.O.), Espoo FI-02044, Finland; Steno Diabetes Center A/S (H.N., M.O.), Gentofte, Denmark; and Child and Family Research
Endocrinology ; 155(10): 3843-52, 2014 Oct.
Article en En | MEDLINE | ID: mdl-25051434
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Islotes Pancreáticos / Intolerancia a la Glucosa / PPAR gamma / Células Secretoras de Insulina / Metabolismo de los Lípidos / Obesidad Idioma: En Revista: Endocrinology Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Islotes Pancreáticos / Intolerancia a la Glucosa / PPAR gamma / Células Secretoras de Insulina / Metabolismo de los Lípidos / Obesidad Idioma: En Revista: Endocrinology Año: 2014 Tipo del documento: Article