Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis.

Works, Melissa G; Yin, Fangfang; Yin, Catherine C; Yiu, Ying; Shew, Kenneth; Tran, Thanh-Thuy; Dunlap, Nahoko; Lam, Jennifer; Mitchell, Tim; Reader, John; Stein, Paul L; D'Andrea, Annalisa

Works, Melissa G; Yin, Fangfang; Yin, Catherine C; Yiu, Ying; Shew, Kenneth; Tran, Thanh-Thuy; Dunlap, Nahoko; Lam, Jennifer; Mitchell, Tim; Reader, John; Stein, Paul L; D'Andrea, Annalisa.

Afiliación

Works MG; Biosciences Division, Center for Immunology and Infectious Diseases, SRI International, Menlo Park, CA 94025; and.
Yin F; Biosciences Division, Center for Immunology and Infectious Diseases, SRI International, Menlo Park, CA 94025; and.
Yin CC; Biosciences Division, Center for Immunology and Infectious Diseases, SRI International, Menlo Park, CA 94025; and.
Yiu Y; Biosciences Division, Center for Immunology and Infectious Diseases, SRI International, Menlo Park, CA 94025; and.
Shew K; Biosciences Division, Center for Immunology and Infectious Diseases, SRI International, Menlo Park, CA 94025; and.
Tran TT; Biosciences Division, Center for Immunology and Infectious Diseases, SRI International, Menlo Park, CA 94025; and.
Dunlap N; Biosciences Division, Center for Immunology and Infectious Diseases, SRI International, Menlo Park, CA 94025; and.
Lam J; Biosciences Division, Center for Immunology and Infectious Diseases, SRI International, Menlo Park, CA 94025; and.
Mitchell T; Sareum, Cambridge CB22 3FX, United Kingdom.
Reader J; Sareum, Cambridge CB22 3FX, United Kingdom.
Stein PL; Biosciences Division, Center for Immunology and Infectious Diseases, SRI International, Menlo Park, CA 94025; and.
D'Andrea A; Biosciences Division, Center for Immunology and Infectious Diseases, SRI International, Menlo Park, CA 94025; and annalisa.dandrea@sri.com.

J Immunol ; 193(7): 3278-87, 2014 Oct 01.

Article en En | MEDLINE | ID: mdl-25156366

Asunto(s)

Dermatitis/tratamiento farmacológico; Interleucina-17/inmunología; Interleucina-23/inmunología; Interleucinas/inmunología; Janus Quinasa 1/antagonistas & inhibidores; Inhibidores de Proteínas Quinasas/farmacología; Psoriasis/tratamiento farmacológico; Transducción de Señal/efectos de los fármacos; TYK2 Quinasa/antagonistas & inhibidores; Animales; Dermatitis/genética; Dermatitis/inmunología; Dermatitis/patología; Modelos Animales de Enfermedad; Relación Dosis-Respuesta a Droga; Humanos; Interferón gamma/genética; Interferón gamma/inmunología; Interleucina-12/genética; Interleucina-12/inmunología; Interleucina-17/genética; Interleucina-23/genética; Interleucinas/genética; Janus Quinasa 1/genética; Janus Quinasa 1/inmunología; Ratones; Ratones Mutantes; Psoriasis/genética; Psoriasis/inmunología; Psoriasis/patología; Proteína Amiloide A Sérica/genética; Proteína Amiloide A Sérica/inmunología; Transducción de Señal/genética; Transducción de Señal/inmunología; TYK2 Quinasa/genética; TYK2 Quinasa/inmunología; Interleucina-22

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Psoriasis / Transducción de Señal / Interleucinas / Interleucina-17 / Inhibidores de Proteínas Quinasas / Dermatitis / Janus Quinasa 1 / TYK2 Quinasa / Interleucina-23 Tipo de estudio: Prognostic_studies Idioma: En Revista: J Immunol Año: 2014 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google