[Soft tissue tumors - the view of the molecular biologist]. / Nádory mekkých tkání ocima molekulárního patologa.
Cesk Patol
; 50(3): 132-40, 2014 Jul.
Article
en Cs
| MEDLINE
| ID: mdl-25186594
ABSTRACT
Soft tissue tumors (SSTs) constitute a broad spectrum of neoplasms with diverse biological properties. Rare or unusual types are often difficult to classify. Recent studies show, that a significant subset of SSTs including many types of sarcomas are associated with specific genetic changes such as chromosomal translocations producing chimeric genes, which play a role in the pathogenesis of SSTs. Because SSTs represent a diagnostically challenging group of tumors, molecular-genetic techniques (FISH or PCR) are useful as supplementary and/or confirmatory diagnostic tools. In the present paper we demonstrate the usefulness of a combined diagnostic approach using the tools of classical histopathology and immunohistochemistry together with the molecular diagnostic approach in selected nosologic entites.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias de los Tejidos Blandos
/
Patología Molecular
Tipo de estudio:
Diagnostic_studies
Idioma:
Cs
Revista:
Cesk Patol
Año:
2014
Tipo del documento:
Article