Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization.

Meinke, Peter; Mattioli, Elisabetta; Haque, Farhana; Antoku, Susumu; Columbaro, Marta; Straatman, Kees R; Worman, Howard J; Gundersen, Gregg G; Lattanzi, Giovanna; Wehnert, Manfred; Shackleton, Sue

Meinke, Peter; Mattioli, Elisabetta; Haque, Farhana; Antoku, Susumu; Columbaro, Marta; Straatman, Kees R; Worman, Howard J; Gundersen, Gregg G; Lattanzi, Giovanna; Wehnert, Manfred; Shackleton, Sue.

Afiliación

Meinke P; Institute of Human Genetics and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.
Mattioli E; National Research Council of Italy - CNR - Institute for Molecular Genetics, Unit of Bologna IOR, Bologna, Italy; Rizzoli Orthopaedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, Italy.
Haque F; Department of Biochemistry, University of Leicester, Leicester, United Kingdom.
Antoku S; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America.
Columbaro M; Rizzoli Orthopaedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, Italy.
Straatman KR; Centre for Core Biotechnology Services, University of Leicester, Leicester, United Kingdom.
Worman HJ; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America; Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America.
Gundersen GG; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America.
Lattanzi G; National Research Council of Italy - CNR - Institute for Molecular Genetics, Unit of Bologna IOR, Bologna, Italy; Rizzoli Orthopaedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, Italy.
Wehnert M; Institute of Human Genetics and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.
Shackleton S; Department of Biochemistry, University of Leicester, Leicester, United Kingdom.

PLoS Genet ; 10(9): e1004605, 2014 Sep.

Article en En | MEDLINE | ID: mdl-25210889

Asunto(s)

Núcleo Celular/metabolismo; Citoesqueleto/metabolismo; Péptidos y Proteínas de Señalización Intracelular/genética; Proteínas de la Membrana/genética; Proteínas Asociadas a Microtúbulos/genética; Distrofias Musculares/genética; Distrofias Musculares/patología; Proteínas Nucleares/genética; Animales; Núcleo Celular/genética; Células Cultivadas; Citoesqueleto/genética; Citoesqueleto/patología; Femenino; Fibroblastos/metabolismo; Fibroblastos/patología; Humanos; Péptidos y Proteínas de Señalización Intracelular/metabolismo; Masculino; Proteínas de la Membrana/metabolismo; Ratones; Proteínas Asociadas a Microtúbulos/metabolismo; Fibras Musculares Esqueléticas/metabolismo; Fibras Musculares Esqueléticas/patología; Distrofias Musculares/metabolismo; Mutación/genética; Mioblastos/metabolismo; Mioblastos/patología; Células 3T3 NIH; Membrana Nuclear/genética; Membrana Nuclear/metabolismo; Membrana Nuclear/patología; Proteínas Nucleares/metabolismo

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Citoesqueleto / Proteínas Nucleares / Núcleo Celular / Péptidos y Proteínas de Señalización Intracelular / Proteínas de la Membrana / Proteínas Asociadas a Microtúbulos / Distrofias Musculares Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2014 Tipo del documento: Article

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