Synchrotron-based photon activation therapy effect on cisplatin pre-treated human glioma stem cells.
Anticancer Res
; 34(10): 5351-5, 2014 Oct.
Article
en En
| MEDLINE
| ID: mdl-25275028
ABSTRACT
BACKGROUND:
Glioblastoma multiforme (GBM) is one of the deadliest cancers characterized by very limited sensitivity to chemo- and/or radiotherapy. The presence of GBM stem-like cells in the tumor might be relevant for GBM treatment resistance.AIM:
To provide a proof-of-concept of the efficacy of photon activation therapy (PAT) using monochromatic synchrotron radiation (SR), in killing GBM stem cells pre-treated with cisplatin. MATERIALS ANDMETHODS:
Irradiation was performed using a 1-8 Gy dose range and energies just above or below the platinum K-shell edge (78.39 keV) or with a conventional X-ray source. Cells were exposed to drug concentrations allowing 90% cell survival, mimicking the unfavourable tissue distribution generally achieved in GMB patients.RESULTS:
a significant enhancement in cell lethality was observed using SR compared to conventional X-ray irradiation.CONCLUSION:
PAT deserved to be further explored in in vivo models based on GBM stem-like cells.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Células Madre Neoplásicas
/
Neoplasias Encefálicas
/
Cisplatino
/
Sincrotrones
/
Fotones
/
Glioblastoma
Idioma:
En
Revista:
Anticancer Res
Año:
2014
Tipo del documento:
Article