Recent advancement in understanding colitis-associated tumorigenesis.
Inflamm Bowel Dis
; 20(11): 2115-23, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-25337866
ABSTRACT
Chronic inflammation predisposes patients with inflammatory bowel disease to the risk of developing colitis-associated cancer (CAC). Growing evidence strongly suggests that CAC development is multifactorial and is attributed to concurrent, dynamic dysregulations in host immunity, enteric microbiota, and epithelial restitution during the course of chronic inflammation. This article discusses the recent advances in understanding the different forms of CAC that may develop in patients with inflammatory bowel disease and animal models, as well as molecular alterations and other processes that orchestrate the development of CAC.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Colitis
/
Neoplasias del Colon
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Inflamm Bowel Dis
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2014
Tipo del documento:
Article